Vaccine side effects, Pain and swelling DBD

VIVAnews -Vaccine dengue fever dengue (DBD) entered the final stages of clinical trials. For in Jakarta, trials done to 800 children organized by the health centers in five regions of Jawa. In East Jakarta, the vaccine is given in Malay Kampongs SD 01 in cooperation with the RSCM.

According to a consultant specialist child RSCM Rini Sekartini, delivery of vaccines to children it is the first time in ASEAN. Before administering vaccines to adults tested in Thailand some time ago. So it is not known whether vaccines DBD can do such as immunization. "Efektitas protection and see if the child fever or not," said Rini on the sidelines of injecting, Wednesday June 8, 2011. Immunization is given gradually up to four weeks.

Rini explains, giving vaccines have side effects of pain and swelling at the former shot for one to three day immunization is given. It is known based on tests of the vaccine in adults. This vaccine is reserved for the children to adulthood. "Dosisnya at 0.5 cc," he added.

Rini reveals, the vaccine is available through research studies cimeric yelllow fever dengue 2 for 25 years in five faculties of Medicine of the five ASEAN countries namely Indonesia, Thailand, Viet Nam, the Philippines, and Malaysia.

To be able to diimuniasi this, further he DBD, parents will be interviewed first. "Asked domicile, the child's health history. After that check your physical, new done injecting, "he explained.

Meanwhile, one of the parents of pupils, Nana sumiarti said he did not fear if his son was injected vaccine DBD. "I want to let my child avoid DBD," Frank he (eh)

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Dengue vaccine Tested today

VIVAnews -Office of Health Jakarta will test vaccines anti dengue fever dengue (DBD). Testing done to 800 ELEMENTARY students in the capital, today, Wednesday 8 June 2011.

According to the Head Office of health, Dien Emmawati, for vaccine delivery is scheduled in Jakarta in the health district of Tambora, Senen, Curry leaf, Pasarminggu, and Jatinegara. "Children who have gone through the stages of selection chosen," he said.

Dien said, they selected vulnerable group exposed to DBD. Once injected with the vaccine DBD, further Dien, 800 children it will be monitored for four years into the future. If it does not cause any interference effects, vaccine ready for sale to the public in 2015.

Also in Jakarta, two major cities in Indonesia also get vaccine anti this quota, the DBD Bandung and Bali. The vaccine is obtained after passing through the research for 25 years in five faculties of Medicine of the five ASEAN countries namely Indonesia, Thailand, Viet Nam, the Philippines, and Malaysia.

During the last three years in Jakarta declined cases DBD significantly. According to the blessing of Dien, a decrease of interpreter monitors water Wiggler spread in every village. Data from the health services (Dinkes) Jakarta mentions, in 2007 the number of cases of DBD reach 31836 cases.

That number decreased in 2008 that only reach 28361 cases. At the 2009 Yixin's demotion until leaving 18835 cases. In 2010 the number of cases continues to shrink until DBD 12639 cases. "Since KLB 2007 significantly decline each year. The number of death also down considerably compared to previous years, "he explained.

Whereas, for 2011 through may case DBD recorded 3597 cases. "Expected If this successful vaccine anti DBD can continue to lower the number of cases DBD in Jakarta," said Dien explained.

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Vaccine for Malaria, TB, and HIV is present in 2020

VIVAnews -Alan Aderem, Director of BioMed and Rino Rappuoli, Seattle, Global Head of Vaccines Research for Novartis Vaccines and Diagonstics, viewing the latest progress in the development of a vaccine in a scientific journal, Nature.

They write, it is estimated, by 2020, a vaccine for malaria, tuberculosis (TB) and HIV/AIDS have been found. In the journal that they also discussed the new devices including biological systems and the design of antigen-based structure that can provide a better understanding of the mechanisms of protection.

This device will give instructions to the rational development of vaccines to burden the people with infectious diseases are the most terrible in the world.

According to Aderem, a pioneer in the field of systems biology, new concepts and advances in technology have indicated that the vaccine to three infectious diseases reveals that will be developed in the next 10 years.

"Success will rely heavily on the ability of the US approach on biological systems to analyze the data generated during the test of proof," said Aderem, like diktutip of MedIndia, may 28, 2011.

Aderem mentions, the success of it will also give a new view, such as the identification of the relationship between protection or signs of immunogenicity and acceleration of large-scale clinical trials. In addition, add Aderem, a regulatory approach to a new and innovative clinic will also accelerate the discovery of vaccines-vaccines are badly needed.

In its report, Aderem and Rappuoli also reviews the advantages and disadvantages of system biology approach, with the main advantage of that approach is in its ability to capture and integrate data of very large amounts of biology to visualize the properties that appear are not indicated by the parts individually and could not be predicted if only use each section singly.

"The advantages of biological system is its ability to predict the behavior of the whole system of biology," said Aderem. "From there, we can optimize the vaccine candidate and to predict whether a drug or vaccine candidate could work before the medication was taken to large scale clinical trials that are very expensive," he said.

Biological systems can also be used to accelerate clinical trials usually last long.

Aderem and Rappuoli estimates that in the trials of a vaccine for malaria, TB and HIV/AIDS, only one hypothesis was tested every eight years in the last three decades. "We cannot continue to use this approach if we want to get in as soon as possible," said Aderem.

With this new method, said Aderem, we can accelerate the development of the clinic by doing a test run is more efficacious and by improving biological system design using approaches to test several hypotheses in parallel and have a design that is adaptive to expand results which proved most promising.

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